Tartrato de vinorelbina 125317-39-7
Descripción del producto
.cp_wz tabla {borde superior: 1px sólido #ccc; borde izquierdo: 1px sólido #ccc; } .cp_wz table td {borde derecho: 1px sólido #ccc; borde inferior: 1px sólido #ccc; padding: 5px 0px 0px 5px;} .cp_wz table th {border-right: 1px solid #ccc; border-bottom: 1px solid #ccc; relleno: 5px 0px 0px 5px;} \ n Peso molecular: \ n 1079.11 El tartrato de vinorelbina es un alcaloide de vinca semisintético e inhibe la mitosis a través de la interacción con la tubulina. \ n Actividad biológica
Protocolo (solo como referencia) Estudio en animales: [5]
Conversión de diferentes modelos de animales basados en BSA (valor basado en datos del Borrador de Directrices de la FDA)
Por ejemplo, para modificar la dosis de resveratrol utilizada para un ratón (22,4 mg / kg) a una dosis basada en el BSA para una rata, multiplique 22,4 mg / kg por el factor Km para un ratón y luego divida por el factor Km para una rata. Este cálculo da como resultado una dosis equivalente para ratas de resveratrol de 11,2 mg / kg.
Información química
Calculadora de molaridad Calculadora de dilución Calculadora de peso molecular
Description | Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. | |||||
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Targets | Tubulin [1] | |||||
In vitro | Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. | |||||
In vivo | In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. | |||||
Features | A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug. |
Animal Models | Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts. |
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Formulation | Sterile 0.9% sodium chloride solution |
Dosages | ~10 mg/kg |
Administration | i.p. |
Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
rat Km(6) |
Molecular Weight (MW) | 1079.11 |
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Formula |
C45H54N4O8.2C4H6O6 |
CAS No. | 125317-39-7 |
Storage | 3 years -20℃Powder |
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6 months-80℃in solvent (DMSO, water, etc.) | |
Synonyms | N/A |
Solubility (25°C) * | In vitro | DMSO | 100 mg/mL (92.66 mM) |
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Water | 100 mg/mL heating (92.66 mM) | ||
Ethanol | 100 mg/mL heating (92.66 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Chemical Name | 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine ditartrate |
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Grupos de Producto : Señalización citoesquelética > Inhibidor asociado a microtúbulos
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